Impacts of ciproxifan on the tissue of the hippocampus in rats with cerebral ischemia-reperfusion

Cerebral ischemia is the result of reduced or interrupted blood flow to the brain. Cerebral ischemia is reversible or irreversible in the neurons of the affected area, and subsequent free radical damage can be exacerbated by reperfusion. Ciproxifan is used to study the involvement of histaminergic neurons in different phases such as wakefulness and cognition. We wanted to find out whether ciproxifan has a protective effect on the hippocampus of rats with cerebral ischemia-reperfusion injury.A total of 32 adult male rats were used for the experiment. Four cages were formed with randomly selected rats. No substance was administered to the rats in group 1 and no surgical intervention was performed. The cerebral ischemia-reperfusion model (left common carotid artery clamping for 15 minutes followed by reperfusion for 24 hours) was applied to the rats in group 2, group 3, and group 4 after administration of 7 days/single dose of saline or ciproxifan (10 mg/kg, 30 mg/kg). The activitymeter and Morris water maze were performed on all animals.The histologic structures of the neurons and glial cells of ciproxifan-treated rats resemble those of the control group, and remarkably, the differences increased with dosage. Rats given ciproxifan showed enhanced learning capacity, reduced total distance behavior, and increased motor coordination. However, there was no discernible change in the parameters when the groups were compared based on sex. We can conclude that ciproxifan has a protective effect on the hippocampus at a certain level.