microtubule

The tubulin code in neuron health and disease : focus on detyrosination

Untitled Seminar

Rachel Moore- Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo Michael Notaras-TBA Rachel Wong- Circuit assembly in the vertebrate retina

Numbing intraneuronal Tau levels to prevent neurodegeneration in tauopathies

Intraneuronal accumulation of the microtubule associated protein Tau is largely recognized as an important toxic factor linked to neuronal cell death in Alzheimer’s disease and tauopathies. While there has been progress uncovering mechanisms leading to the formation of toxic Tau tangles, less is known about how intraneuronal Tau levels are regulated in health and disease. Here, I will discuss our recent work showing that the intracellular trafficking adaptor protein Numb is critical to control intraneuronal Tau levels. Inactivation of Numb in retinal ganglion cells increases monomeric and oligomeric Tau levels and leads to axonal blebbing in optic nerves, followed by significant neuronal cell loss in old mice. Interestingly, overexpression of the long isoform of Numb (Numb-72) decreases intracellular Tau levels by promoting exocytosis of monomeric Tau. In TauP301S and triple transgenic AD mouse models, expression of Numb-72 in RGCs reduces the number of axonal blebs and prevents neurodegeneration. Finally, inactivation of Numb in TauP301S mice accelerates neurodegeneration in both the retina and spinal cord and leads to precocious paralysis. Taken together, these results uncover Numb as a essential regulator of Tau homeostasis in neurons and as a potential therapeutic agent for AD and tauopathies.

A novel role for Janus Kinase and Microtubule-Interacting Protein 1 (JAKMIP1) in modulating Signal Transducer and Activator of Transcription-3 (STAT3)-mediated cytokine signalling in neuronal cells

CDKL5’s role in microtubule-based transport and cognitive function

The Effect of Radiofrequency Electromagnetic Fields on Neuronal Activity: Implication of Microtubules

Fidgetin-like 1, a novel regulator of the microtubule/actin crosstalk required for axon outgrowth and navigation

Janus Kinase and Microtubule-Interacting Protein 1 (JAKMIP1), a novel regulator of nuclear RNA export in neurons: coupling transcription to cytoplasmic translation through the microtubule cytoskeleton

Neuronal MAP6 coordinates actin and microtubule nucleation in vitro

Polyglutamylation of microtubules drives motor axon remodelling

Screening tyrosine kinases for their involvement in synaptotoxicity induced by tau microtubule-binding region fibrils

Sex-specific regulation of NMDAR-independent long-term depression by the microtubule-associated protein tau

Visualization of MAP6-positive microtubules throughout the neuronal MT network: input of expansion microscopy

In vitro microfluidic design to study mitochondria-microtubules interactions after an axonal traumatic injury

Microtubule depolymerization contributes to spontaneous neurotransmitter release

FENS Forum 2024

Novel lissencephaly-associated DCX variants affect microtubule binding, dynamics, and neuronal migration

FENS Forum 2024

A novel microtubule doublet regulator in neuronal primary cilia

FENS Forum 2024

Physiological measurements of activity and microtubule health in human iPSC-derived neurons using fluorescence and second harmonic microscopy

FENS Forum 2024

Synaptic control of microtubule organisation in parvalbumin interneurons

FENS Forum 2024

Towards a mathematical model of microtubules in neurites

FENS Forum 2024

Upregulation of Stathmin-2 induces microtubule-dependent synaptic modifications during the rewiring of neuronal connectivity

FENS Forum 2024